Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes Cagrilintide & Semaglutide in Overweight Adults (REDEFINE 1) NEJM Med Journal Club YouTube New in the August 14, 2025, issue of NEJM: CagrilintideSemaglutide for Overweight or Obesity (REDEFINE 1 phase 3a trial) Cagrilintide Semaglutide for Overweight and Diabetes (REDEFINE 2 phase 3a trial)
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coadministered cagrilintide and semaglutide in adults with overweight or obesity 1 CagriSema 2.4 mg / 2.4 mg FDA NDA filing; Novo Nordisk data on file. 2 Garvey WT, Blüher M, Osorto Contreras CK, et al. Coadministered cagrilintide and semaglutide in adults with