Simplified scheme of APAP metabolism, leading to the formation of NAPQI Download Scientific Diagram Mechanisms of Hepatocyte Detoxification Abdominal Key An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen glutathione conjugate, a non toxic metabolite