Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. A study published in Gastroenterology describes a new mitochondrial mediator in the hepatotoxicity induced by paracetamol. Institute of Biomedical Research of Barcelona Paracetamol Induced Hepatotoxicity , Overdose NAPQI formation Glutathione depletion Liver cell necrosis. Early N acetylcysteine (NAC) can save the liver., #Pharmacology #mbbs #Hepatotoxicity IAOS Indian Academy of Orthopaedic Surgeons