Frontiers HGF and MET: From Brain Development to Neurological Disorders Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Small Molecule AngIV based Analogs to Treat Alzheimers Disease Growth factors and their peptide mimetics for treatment of traumatic brain injury ScienceDirect
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dihexa synaptogenesis neurogenesis Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling dysfunction