B12 Shots & B12 Injections: The Good, Bad and Alternative! Feeling worse after B12 Injection: Answering concerns. La Vie Med Spa A new research study led by Mayo Clinic is comparing three commonly prescribed medications used to prevent migraine: atogepant, propranolol, and topiramate. The goal of the study is to better understand how B12 Shots at Home: How, Where & How Often to Inject Yourself AZ IV Medics