Best Ingredients for Melasma Do You Need All These Ingredients for Melasma? No. You don't need to use everything at once. Using too many strong actives can irritate the skin and worsen Buy Thiamidol For Melasma Pigmentation: Dermatologist Review Effective Tyrosinase Inhibition by Thiamidol Results in Significant Improvement of Mild to Moderate Melasma ScienceDirect I layer multiple brightening ingredients to keep my skin tone even and fade dark spots. In the mornings, I use a vitamin C antioxidant serum + thiamidol, and (pre pregnancy) a retinoid at