Critical Role of Antidotes in Managing : Annals of African Medicine Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification A guide to managing acute liver failure Cleveland Clinic Journal of Medicine