Early research into L carnitine was often cited as underwhelming, showing negligible changes in muscle carnitine content and fat loss outcomes. However, these findings may have been limited by a short study window The adverse effects of long term l carnitine supplementation on liver and kidney function in rats L Liu, D M Zhang, M X Wang, C Y Fan, F Zhou, S J Wang, L D Kong, 2015 History of L carnitine: Implications for renal disease Journal of Renal Nutrition Protective effects of l carnitine on isoprenaline induced heart and kidney dysfunctions: Modulation of inflammation and oxidative stress related gene expression in rats ScienceDirect
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l-carnitine effects on kidney L-Carnitine | Linus Pauling Institute