Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? Why you should avoid REGULAR acetaminophen use for babies and pregnancy 3 Little Plums Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. A guide to managing acute liver failure Cleveland Clinic Journal of Medicine