Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Acetaminophen for Kids: Safety, Myths, and What Parents Should Know Heres why you should avoid Tylenol , First of all, it is full of colorful dyes, sugars and additives. , But the main reason it is it depletes glutathione. , Glutathione is one of the most Figure 1 from Acetaminophen toxicity and 5 oxoproline (pyroglutamic acid): a tale of two cycles, one an ATP depleting futile cycle and the other a useful cycle. Semantic Scholar