Individuals with MTHFR mutations and slow COMT activity can generally take N acetylcysteine (NAC) and glutathione, but there are some important considerations: ## N Acetylcysteine (NAC) * **Benefits**: NAC supports the production of glutathione, NAC vs. Glutathione and How They Work Invigor Medical Oral N acetylcysteine ameliorates liver fibrosis and enhances regenerative responses in Mdr2 knockout mice Scientific Reports N Acetylcysteine improves intestinal function and attenuates intestinal autophagy in piglets challenged with conglycinin Scientific Reports