Does Acetaminophen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA CCL SUPPLEMENTS Advanced Glutathione Spray & NAC Supplement, Liquid Glutathione Sublingual, N Acetyl cysteine Antioxidant Spray Supports Immune Health Fresh Flavor, Non GMO, Vegan, Gluten Free (2 Fl Oz) Best Price KSA Riyadh, Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.