Tylenol And Glutathione Invigor Medical Frontiers Potential adverse actions of prenatal exposure of acetaminophen to offspring Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram