Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Clinically relevant therapeutic approaches against acetaminophen hepatotoxicity and acute liver failure ScienceDirect Too Much of a Good Thing: Inadvertent Acetaminophen Overdose in a Low Weight, Elderly Patient