OXIDATIVE STRESScan contribute to hypothyroid symptoms When the body has to deal with too much Oxidative Stress from inflammation, then the enzyme Glutathione Peroxidase [GPx] has to work overtime to inactivate damaging " l Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway ScienceDirect Involvement of glutaredoxin 1 and thioredoxin 1 in amyloid toxicity and Alzheimer's disease Cell Death & Differentiation Sulfur metabolism under stress: Oxidized glutathione inhibits methionine biosynthesis by destabilizing the enzyme cystathionine < em> synthase