Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it When Good Drugs Go Bad: Acetaminophen Toxicity tl;dr pharmacy They told us Tylenol is safe. Pediatricians recommend them daily. But what if we've been missing the full story? Research shows that frequent use of acetaminophen (Tylenol) in babies and children Acetaminophen Toxicity Toxicology UWorld Medical Library