Glutathione for skin lightening Dermatologist explains Glutathione Treatment Glutathione Skin Lightening Oral glutathione has been everyone on my timeline but does it actually work?! Looking at the data, its very modest to be honest. Id recommend sticking to what we know works fo hyperpigmentation in Effect of an Oral Formulation on Skin Lightening: Results from In Vitro Tyrosinase Inhibition to a Double Blind Randomized Placebo Controlled Clinical Study in Healthy Asian Participants