GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Acetaminophen, ethanol and other co ingestions ScienceDirect Figure 1: CMAJ
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glutathione acetaminophen Recurrent Pyroglutamic Acidosis Related to Therapeutic Acetaminophen