Lipid orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts: Immunity Frontiers Ironing out COPD: ferroptosis driven immune dysregulation, metabolic rewiring, and precision therapeutic opportunities Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Recruitment or activation of mast cells in the liver aggravates the accumulation of fibrosis in carbon tetrachloride induced liver injury ScienceDirect