The changing faces of glutathione, a cellular protagonist., Volume I Frontiers Research Topic Glutathione responsive and mitochondria targeting enhanced photodynamic therapy and cascade triggered carbon monoxide release for all in one tumor therapy ScienceDirect The Role of the Glutathione System in Stress Adaptation, Morphogenesis and Virulence of Pathogenic Fungi Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.