The methylation cycle and glutathione synthesis pathway. Metabolites Download Scientific Diagram Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Californians push back against proposed restrictions on glutathione and other alternative treatments Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect