Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram