Prescription Medications That Deplete Nutrients OC Integrative Medicine How Glutathione is Depleted from the Body Suzy Cohen, RPh offers natural remedies to help you feel better now! What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.