Amide Hydrolysis Using Acid Or Base Master Organic Chemistry Condensation and Hydrolysis Reactions (M12Q6) CHEM 104: Working Copy Mechanistic investigations of the hydrolysis of amides, oxoesters and thioesters via kinetic isotope effects and positional isotope exchange ScienceDirect Reactions of Amides a) Hydrolysis Amides can break back into the acid and amine when heated with: Strong acid Strong base Example: Amide + HO Carboxylic acid + Amine b) Reduction
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