What Caused These Multiple Hyperpigmented Macules of the Mouth? Pathology Outlines Melanotic macule Figure 2 from Smokers' melanosis in a Nigerian population: Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association
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