Calming the Chaos: How Ozone and Light Therapy Help with Mast Cell Activation Syndrome (MCAS) in Oklahoma City Venturis Clinic Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the Differentiating Changes in Glutathione Levels from Cytotoxic Events Using Multiplexed Assays