Cagrilintide & Semaglutide in Overweight Diabetics (REDEFINE 2) NEJM Med Journal Club Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Mediocre results from the Phase 3a trial for cagrilintide and semaglutide #CagriSema in obesity and type 2 diabetes. Average weight loss at week 68 was 13.7% in the CagriSema group and 3.4% CagrisSema is a once weekly injection of semaglutide and cagrilintide. Phase 2 clinical trial results for CagriSema showed significant improvements in A1C, weight loss, and time in range, marking it as a promising
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cagrilintide clinical trials results Efficacy and safety of cagrilintide 2.4 mg in adults with overweight/obesity: Data from REDEFINE 1