Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg kg intravenous acetaminophen in very preterm infants Pediatric Research The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Can Tylenol (acetaminophen) deplete glutathione levels in the body?