How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Figure 2. [Growth hormone binding to the]. Endotext NCBI Bookshelf Intestinal Gastrin CCKBR (Cholecystokinin B Receptor) Ameliorates Salt Sensitive Hypertension by Inhibiting Intestinal Na+ H+ Exchanger 3 Activity Through a PKC (Protein Kinase C) Mediated NHERF1 and NHERF2 Pathway Hypertension Peptide Therapy for Inflammation: A New Solution