Carnitine: Top 3 Anti Aging Benefits of This Super Nutrient Oxidation of Fatty Acids: Ketogenesis Basicmedical Key Short Note On Carnitine Shuttle: Fatty acids are oxidized in mitochondria, and synthesized in the cytoplasm. Long chain fatty acids must form an active intermediate, fatty acyl CoA, before being oxidized inside mitochondria. Catherine Nutritional and Hormonal Regulation of Citrate and Carnitine Acylcarnitine Transporters: Two Mitochondrial Carriers Involved in Fatty Acid Metabolism