Glutathione Strive Pharmacy Energy metabolism inhibition downregulates glutathione and heat shock proteins for synergistically enhancing oxidative stress and photothermal therapy ScienceDirect Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth: Cell Reports