Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted A novel agonist for the HGF receptor MET promotes differentiation of human pluripotent stem cells into hepatocytelike cells Tauran 2022 Development, Growth & Differentiation Wiley Online Library Recent advances in the discovery of small molecule c Met Kinase inhibitors ScienceDirect The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases ScienceDirect
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dihexa hgf/c-met agonist Structural basis of the activation of c-MET receptor