Oral melanoma and other pigmentations: when to biopsy? Lambertini 2018 Journal of the European Academy of Dermatology and Venereology Wiley Online Library Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Semantic Scholar Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule.