PDF) Implications of Altered Glutathione Metabolism in Aspirin Induced Oxidative Stress and Mitochondrial Dysfunction in HepG2 Cells Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Tylenol's Impact on Glutathione and Liver Damage Puregen Labs Aspirin 81mg, Enteric Coated, Low Dose, Caffeine Free, 300 Tablets Walmart.com