Ozonating coffee enemas combines two powerful therapies. The coffee stimulates hepatic glutathione S transferase, upregulating detoxification pathways in the liver. It also increases glutathione A refined approach to wellness , The aim of the coffee in an enema is to help clean the colon and stimulate the liver. This enema is said to help stimulate glutathione production by the liver, which Enema Coffee 1lb Perfectly Healthy Gwyneth Paltrow's lifestyle 'detox guide' promotes coffee enema. Experts say it's bogus.