Will L Carnitine help you with insulin resistance? We have study results! YouTube L carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact ScienceDirect L Carnitine has become one of our top 5 sellers this year and I can see why when looking at all the research that has come out about it over the last few Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: A randomised controlled trial eBioMedicine