A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 S allyl glutathione, a synthetic analogue of glutathione protected liver against carbon tetrachloride toxicity: Focus towards anti oxidative efficiency ScienceDirect Frontiers Glutathione: Pharmacological aspects and implications for clinical use in non alcoholic fatty liver disease Glutathione in the Treatment of Fatty Liver NASH NAFLD