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NSAIDs & Acetaminophen Clinical Pharmacology Flashcards ditki medical and biological sciences GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Metabolic pathway for NAPQI formation and detoxification by conjugation Download Scientific Diagram
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acetaminophen blocks glutathione 54
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