Targeting Skeletal Muscle Dysfunction With L Carnitine for the Treatment of Patients With Chronic Obstructive Pulmonary Disease In Vivo Combined metabolic activators to treat mitochondrial dysfunction Mitochondrial dysfunction is a common feature of many human diseases and is emerging as a therapeutic target. Systems biology and multiomics approaches have revealed that Carnitine Deficiency: What Is It, Causes, Symptoms, and More Osmosis Muscle Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility: Cell Metabolism