Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination Cagrilintide lowers bodyweight through brain amylin receptors 1 and 3 eBioMedicine Development of Cagrilintide, a Long Acting Amylin Analogue Journal of Medicinal Chemistry Amylin as a future obesity treatment introducing cagrilintideNote significant GI adverse effects cf. placebo but no apparent plateauing of weight loss after 26 weeks