7 While the increased osmotic load of sorbitol was initially felt to be a part of the pathogenesis of diabetic complications, it's less clear that this plays a role. Instead, something else Mitochondrial reactive oxygen species generation and antioxidant defense systems MedLink Neurology Schematic summary of glutathione synthesis, catabolism, regulation and Download Scientific Diagram Laboratoire de Chimie Bioorganique et Mdicinale