Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Unveiling the molecular basis of paracetamol induced hepatotoxicity: Interaction of N acetyl p benzoquinone imine with mitochondrial succinate dehydrogenase ScienceDirect Can paracetamol (acetaminophen) be administered to patients with liver impairment? Hayward 2016 British Journal of Clinical Pharmacology Wiley Online Library Kantify Improving Human Health through Artificial Intelligence
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paracetamol and glutathione depletion Yes — there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors