Tylenol's Impact on Glutathione and Liver Damage A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Tylenol lowers glutathione, which is why it can cause liver failure. Low glutathione can cause many serious health problems that can vary from person to person. Finding out if you have genes that can