Acetaminophen causes neurodevelopmental injury in susceptible babies and children: no valid rationale for controversy Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Do You Reach for Tylenol Often? Whether it's for pain, headaches, or fever Tylenol (acetaminophen) is one of the most commonly used medications. But here's something most people don't realize Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation